Factors Affecting The Intensity Of Poisoning

By @forensicfield

Introduction

The resultant of poisoning depends on many factors.

There are number of reasons which can affect intensity of poisoning are further explained, such as;

  • Dose.
  • Time of intake
  • Way of taking
  • Environmental factors, etc.

Dose

Amount of the poison is determine the affect of it on the body. Smaller the dose, lighter the effect and larger the dose, severe the effect.

Resistance

After doing continuous use of some drugs, such as opiates, tobacco, alcohol, etc. person develop a resistance towards some drugs.

Incompatible Combination of Drugs

Ingestion of some incompatible combination of Medicines may be fatal. Such As; Prozac and Tramadol, Thyroid medication and proton pump inhibitors, Nonsteroidal anti-inflammatory drugs and antihypertensive, etc.

Hypersensitivity

Some of persons show abnormal response (idiosyncrasy) to a drug like morphine, quinine, aspirin etc. due to inherent personal hypersensitivity.

Allergy

Some persons are allergic (acquired hypersensitivity) towards certain drugs like penicillin, sulpha, etc.

Incompatible Combinations

Ingestion of certain medications like anti – ulcerous gels with aspirin may lead to fatal effects.

Tolerance

People develop a marked tolerance in the case of opium, alcohol, strychnine, tobacco, arsenic and some other narcotic drugs by repeated and continued use.

Synergism

Some poisonous drugs can be toxic when taken together may cause lethal effect. Such as; Alcohol and Benzodiazepines, Heroine and Cocaine, Benzodiazepines and Opioids, Alcohol and Opioids

Slow Poisons

The continuous small amount of poison ingestion like arsenic, strychnine, lead, etc. accumulate in body and may cause death.

Conditions of The Body

  • Conditions of the body, i.e. age, health, etc. also affect the action of the poison.
  • Generally old persons, weaker persons and children severly affected by low dose of poison then young and healthy person.

Cumulative Action

The repeated small doses of cumulative poisons like arsenic, lead, mercury, strychnine, digitalis etc. may cause death or chronic poisoning by cumulative action.

Shock

Some times, a large dose of a poison acts differently from a small dose, for example; a large dose of arsenic may cause death by shock while a small dose results in diarrhoea.

Forms of Poison

  • Gases/Vapours Poisons
  • Liquid Poisons
  • Powder Poisons
  • Chemical Combination
  • Mechanical Combination

Gases / Vapours Poisons

These types of poison absorbed immediately and act quickly.

Liquid Poisons

These act better than solids.

Powder Poisons

Fine powdered poison act fast than coarse powdered poison.

Chemical Combination

Some substances in combination act like lethal, such as; acids and alkali’s, strychnine and tannic acid, etc.

Mechanical Combination

The action of a poison is altered when combined mechanically with inert substances, such as; when alkaloid when taken with charcoal, it does not act.

Methods Of Administration

A poison acts more rapidly when inhaled in gaseous form or when injected intravenously.

Next when inject intramuscularly or subcutaneously.

A poison acts slowly when swallowed or applied on skin.

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